Pierson Creek or Pearson Creek is a stream in southeastern Greene County in the Ozarks of southwest Missouri. The stream is a tributary of the James River.
The source area for the stream is about two miles west of Strafford and the stream flows south passing under I-44 then turns to the southwest. The stream enters the eastern portion of Springfield and turns south again as it crosses under Cherry Street. It flows under Missouri Route D and joins the James River about three miles northeast of the U.S. Route 60/U.S. Route 65 interchange of south Springfield.Galloway, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1960 (1978 ed.)Missouri Atlas & Gazetteer, DeLorme, 1998, First edition, p. 52,
The stream headwaters are at and the confluence with the James River is at . The confluence is at an elevation of and the elevation of the source is approximately .Bassville, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1961
The stream is the location of the type section for the Pierson Limestone as exposed near the Route D crossing.Thompson, Thomas L., 2001, Lexicon of Stratigraphic Nomenclature in Missouri, Missouri Department of Natural Resources, Division of Geology and Land Survey, Report of Investigation Number 73, p 222
The stream was named for a mill on the stream which was built by Jerry Pearson in 1828–31. Pearson had acquired rights to the property from the Delaware Indians.Greene County Place Names, 1928-1945; The State Historical Society of Missouri
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