Cutolo is an Italian surname. Notable people with the surname include:
Alessandro Cutolo (1899–1995), Italian academic, television presenter, actor and historian Aniello Cutolo (born 1983), Italian footballer Frank Cutolo (born 1976), American player of Canadian football Myriam Cutolo (born 1984), Italian yacht racer Raffaele Cutolo (1941–2021), Italian crime boss Rosetta Cutolo (1937–2023), sister of Raffaele Cutolo William Cutolo (1949–1999), American mobster