Hoss may refer to:
People Hoss (surname), a list of people Höss (surname), a German surname, including a list of people Hoss (nickname), a list of people "Blackjack" Hoss Taylor, a professional wrestler from NWA All-Star Wrestling
Fictional characters Hoss Cartwright, in the television western Bonanza Hoss Delgado, in the animated television series The Grim Adventures of Billy and Mandy Harry Dresden, a detective in the series The Dresden Files Hoss (comics), a Marvel Comics character Hoss, in the animated film Extinct
Music HOSS Records, an American experimental independent record label formed in 2004 Hoss (band), a hard rock band Hoss (album), Lagwagon's third album
Sport Da Hoss, an American racehorse Hoss, a professional wrestling term for a wrestler who is physically large and has an aggressive style
Other uses Hoss's Steak and Sea House, aka "Hoss's"