Guillermo Durán and Máximo González were the defending champions at the doubles at the 2016 Santiago Challenger tennis tournament, but only González chose to defend his title, with partner Sergio Galdós. González lost in the final to Julio Peralta and Horacio Zeballos.
Peralta and Zeballos won the title after defeating Galdós and González 6–3, 6–4 in the final.
Seeds
Draw
References Main draw