Yeprem, also spelt Yefrem, is an Armenian and Russian masculine given name. It is the Armenian spelling of Ephraim. It may refer to:
Yeprem Khan (1868–1912), born Yeprem Davidian, Iranian-Armenian revolutionary leader Yefrem Mukhin (1766–1850), Russian physician and biologist Yeprem Philibosian, Armenian American philanthropist Yefrem Sokolov (1926–2022), Belarusian politician Yeprem I of Constantinople, Armenian Patriarch of Constantinople from 1684 to 1686; see List of Armenian Patriarchs of Constantinople
See also Yepremyan / Yepremian, a surname