California Proposition 65 list of chemicals

The following is a list of chemicals published as a requirement of Safe Drinking Water and Toxic Enforcement Act of 1986, commonly known as California Proposition 65, that are "known to the state to cause cancer or reproductive toxicity" as of January 3, 2020.The Proposition 65 List As a result of lawsuits, the list also contains substances known only to cause cancer in animals.

This list is not exhaustive, as the complete list contains over 900 chemicals.

Chemicals currently listed under California Proposition 65

+Current Proposition 65 list SubstanceReason CAS Registry Number †Date Listed A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole)Cancer26148-68-5January 1, 1990 1,4-Dichloro-2-nitrobenzeneCancer89-61-2September 13, 2019 p-chloro-α,α,α-trifluorotoluene (para-Chlorobenzotrifluoride, PCBTF)Cancer98-56-6June 28, 2019 BevacizumabDevelopmental Reproductive toxicity (female, male)216974-75-3March 8, 2019 AflatoxinsCancer ---January 1, 1988 Ceramic fibers (airborne particles of respirable size)Cancer ---February 27, 1987 Certain combined chemotherapy for lymphomasCancer ---February 27, 1987 para-NitroanisoleCancer100-17-4September 13, 2019 2,4-Dichloro-1-nitrobenzeneCancer611-06-3September 13, 2019 Δ9-Tetrahydrocannabinol (Δ9-THC)DevelopmentalJanuary 3, 2020 2-ChloronitrobenzeneCancer88-73-3September 13, 2019 2-Amino-4-chlorophenolCancer95-85-2September 13, 2019 Cannabis (marijuana) smokeDevelopmental ---January 3, 2020 Abiraterone acetateDevelopmental Reproductive toxicity (female, male)154229-18-2April 8, 2016 AcetaldehydeCancer75-07-0April 1, 1988 AcetamideCancer60-35-5January 1, 1990 AcetazolamideDevelopmental59-66-5August 20, 1999 AcetochlorCancer34256-82-1January 1, 1989 Acetohydroxamic acidDevelopmental546-88-3April 1, 1990 2-AcetylaminofluoreneCancer53-96-3July 1, 1987 Acifluorfen sodiumCancer62476-59-9January 1, 1990 AcrylamideCancer Developmental Reproductive toxicity (male)79-06-1January 1, 1990 February 25, 2011 AcrylonitrileCancer107-13-1July 1, 1987 Actinomycin DCancer Developmental50-76-0October 1, 1989 October 1, 1992 AF-2 ([2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide)Cancer3688-53-7July 1, 1987 AlachlorCancer15972-60-8January 1, 1989 Alcoholic beverages Alcoholic beverages, when associated with alcohol abuseCancer ---April 29, 2011 July 1, 1988 AldrinCancer309-00-2July 1, 1988 All-trans retinoic acidDevelopmental302-79-4January 1, 1989 Aloe vera, non-decolorized whole leaf extractCancer–December 4, 2015 AlprazolamDevelopmental28981-97-7July 1, 1990 AltretamineDevelopmental Reproductive toxicity (male)645-05-6August 20, 1999 Amantadine hydrochlorideDevelopmental665-66-7February 27, 2001 Amikacin sulfateDevelopmental39831-55-5July 1, 1990 2-AminoanthraquinoneCancer117-79-3October 1, 1989 p-AminoazobenzeneCancer60-09-3January 1, 1990 o-AminoazotolueneCancer97-56-3July 1, 1987 4-Aminobiphenyl (4-amino-diphenyl)Cancer92-67-1February 27, 1987 1-Amino-2,4-dibromoanthraquinoneCancer81-49-2August 26, 1997 3-Amino-9-ethylcarbazole hydrochlorideCancer6109-97-3July 1, 1989 2-AminofluoreneCancer153-78-6January 29, 1999 AminoglutethimideDevelopmental125-84-8July 1, 1990 AminoglycosidesDevelopmental–October 1, 1992 1-Amino-2-methylanthraquinone (Disperse Orange 11)Cancer82-28-0October 1, 1989 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazoleCancer712-68-5July 1, 1987 4-Amino-2-nitrophenolCancer119-34-6January 29, 1999 AminopterinDevelopmental Reproductive toxicity (female)54-62-6July 1, 1987 Amiodarone hydrochlorideDevelopmental Reproductive toxicity (female, male)19774-82-4August 26, 1997 AmitrazDevelopmental33089-61-1March 30, 1999 AmitroleCancer61-82-5July 1, 1987 AmoxapineDevelopmental14028-44-5May 15, 1998 AmsacrineCancer51264-14-3August 7, 2009 Anabolic steroidsReproductive toxicity (female, male)–April 1, 1990 AndrostenedioneCancer63-05-8May 3, 2011 ACE inhibitors (Angiotensin converting enzyme)Developmental–October 1, 1992 AnilineCancer62-53-3January 1, 1990 Aniline hydrochlorideCancer142-04-1May 15, 1998 o-AnisidineCancer90-04-0July 1, 1987 o-Anisidine hydrochlorideCancer134-29-2July 1, 1987 AnisindioneDevelopmental117-37-3October 1, 1992AnthraceneCancer120-12-7August 11, 2023 AnthraquinoneCancer84-65-1September 28, 2007 Antimony oxide (Antimony trioxide)Cancer1309-64-4October 1, 1990 AramiteCancer140-57-8July 1, 1987 Areca nutCancer–February 3, 2006 Aristolochic acidsCancer–July 9, 2004 Arsenic (inorganic arsenic compounds)Cancer–February 27, 1987 Arsenic (inorganic oxides)Developmental–May 1, 1997 AsbestosCancer1332-21-4February 27, 1987 Aspirin during the last three months of pregnancyDevelopmental Reproductive toxicity (female)50-78-2July 1, 1990 AtenololDevelopmental29122-68-7August 26, 1997 AtrazineDevelopmental Reproductive toxicity (female)1912-24-9July 15, 2016 AuramineCancer492-80-8July 1, 1987 AuranofinDevelopmental34031-32-8January 29, 1999 Avermectin B1 (Abamectin)Developmental71751-41-2December 3, 2010 AzacitidineCancer320-67-2January 1, 1992 AzaserineCancer115-02-6July 1, 1987 AzathioprineCancer Developmental446-86-6February 27, 1987 September 1, 1996 AzobenzeneCancer103-33-3January 1, 1990 BarbituratesDevelopmental–October 1, 1992 Beclomethasone dipropionateDevelopmental5534-09-8May 15, 1998 BenomylDevelopmental Reproductive toxicity (male)17804-35-2July 1, 1991 Benthiavalicarb-isopropylCancer177406-68-7July 1, 2008 Benz[a]anthraceneCancer56-55-3July 1, 1987 BenzeneCancer Developmental Reproductive toxicity (male)71-43-2February 27, 1987 December 26, 1997 Benzidine (and its salts)Cancer92-87-5February 27, 1987 Benzidine-based dyesCancer–October 1, 1992 BenzodiazepinesDevelopmental–October 1, 1992 Benzo[b]fluorantheneCancer205-99-2July 1, 1987 Benzo[j]fluorantheneCancer205-82-3July 1, 1987 Benzo[k]fluorantheneCancer207-08-9July 1, 1987 BenzofuranCancer271-89-6October 1, 1990 BenzophenoneCancer119-61-9 Benzo[a]pyreneCancer50-32-8 BenzotrichlorideCancer98-07-7 Benzphetamine hydrochlorideDevelopmental5411-22-3 Benzyl chlorideCancer100-44-7 Benzyl violet 4BCancer1694-09-3July 1, 1987 Beryllium and beryllium compoundsCancer– Betel quid with tobaccoCancer– Betel quid without tobaccoCancer– 2,2-Bis(bromomethyl)-1,3-propanediolCancer3296-90-0 Bis(2-chloroethyl)etherCancer111-44-4 N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine)Cancer494-03-1 Bischloroethyl nitrosourea (BCNU, Carmustine)Developmental154-93-8July 1, 1987 Bis(chloromethyl)etherCancer542-88-1 Bis(2-chloro-1-methylethyl)etherCancer– Bisphenol A (BPA)Reproductive toxicity (female) Developmental80-05-7May 11, 2015 December 18, 2020Bisphenol SReproductive toxicity (female, male)80-09-1December 29, 2023 January 3, 2025 Bitumen, extracts of steam-refined and air refinedCancer– Bracken fernCancer– Bromacil lithium saltDevelopmental, Reproductive toxicity (male)53404-19-6May 18, 1999 January 17, 2003 BromateCancer15541-45-4 Bromochloroacetic acidCancer5589-96-8 Bromodichloroacetic acidCancer71133-14-7 BromodichloromethaneCancer75-27-4 BromoethaneCancer74-96-4December 22, 2000 BromoformCancer75-25-2 1-Bromopropane (1-BP)Cancer Developmental Reproductive toxicity (female, male)106-94-5August 5, 2016 December 7, 2004 2-Bromopropane (2-BP)Cancer Reproductive toxicity (female, male)75-26-3August 11, 2023 May 31, 20051-Bromo-3-chloropropaneCancer109-70-6 BromoxynilDevelopmental1689-84-5October 1, 1990 Bromoxynil octanoateDevelopmental1689-99-2 Butabarbital sodiumDevelopmental143-81-7 1,3-ButadieneCancer Developmental Reproductive toxicity (female, male)106-99-0April 1, 1988 April 16, 2004 1,4-Butanediol dimethanesulfonate (Busulfan)Cancer Developmental55-98-1February 27, 1987 January 1, 19891-Butyl glycidyl etherCancer2426-08-6 Butylated hydroxyanisoleCancer25013-16-5 Butyl benzyl phthalate (BBP)Developmental85-68-7 beta-ButyrolactoneCancer3068-88-0July 1, 1987 Cacodylic acidCancer75-60-5 Cadmium and cadmium compoundsDevelopmental Reproductive toxicity (male) Cancer–May 1, 1997 October 1, 1987 Caffeic acidCancer331-39-5 CaptafolCancer2425-06-1 CaptanCancer133-06-2 CarbamazepineDevelopmental298-46-4 CarbarylCancer Developmental Reproductive toxicity (female, male)63-25-2February 5, 2010