McCaskill is a surname. Notable people with the surname include:
Alton McCaskill (born 2003), American football player Amal McCaskill (born 1973), American professional basketball player Billie June McCaskill (1930 – 2011), American herbarium curator Claire McCaskill (born 1953), U.S. Senator from Missouri Ted McCaskill (1936 – 2016), Canadian professional hockey player Ian McCaskill (1938 – 2016), British weatherman Kirk McCaskill (born 1961), Canadian professional baseball player and son of Ted Vern McCaskill (1902 – 1992), American nurseryman of Camellias and Irises, the father of Billie June.
See also MacAskill (disambiguation)