Defrance or DeFrance may refer to: Chris DeFrance (born 1956), a former American football player Hélène Defrance (born 1986), French sailor Jacques Louis Marin DeFrance (1758-1850), a French malacologist Jean-Marie Defrance (1771–1835), a French General of the French Revolutionary Wars and the Napoleonic Wars Jules Defrance, a Belgian racing cyclist Léonard Defrance (1735-1805), a Flemish painter