Spender is a surname. Notable people with the name include:
Dale Spender (1943–2023), Australian feminist and writer Elizabeth Spender, English film actress Emily Spender, English novelist Humphrey Spender (1910–2005), British photographer, painter and designer Jeffrey Spender (judge), Australian judge Jérémy Spender (born 1982), French footballer John Spender (1935–2022), Australian politician and barrister John Alfred Spender (1862–1942), British journalist and newspaper editor Lillian Spender (1835–1895), English novelist Mary Spender (born 1990), British singer-songwriter, guitarist and YouTube personality Matthew Spender (1945–2026), English sculptor and writer Michael Spender (1906–1945), English explorer Nancy Spender (1909–2001), English painter Natasha Spender (1919–2010), English pianist and author Percy Spender (1897–1985), Australian politician, diplomat and jurist Philip Spender (born 1943), English public-sector fundraiser Simon Spender (born 1985), Welsh footballer Stephen Spender (1909–1995), British poet, novelist and essayist Wilfrid Spender (1876–1960), British army officer Herbert Henry Spender-Clay (1875–1937), English soldier and Conservative Party politician
Fictional C.G.B. Spender, fictional character in the American television series The X-Files Cassandra Spender, fictional character in The X-Files Freddie Spender, fictional detective in the British television series Spender Jeffrey Spender, fictional character in The X-Files