Angelopoulos () is a Greek surname meaning "son of Angelos". The feminine form is Angelopoulou (Αγγελοπούλου). Notable people with the surname include:
Athanasios Angelopoulos (born 1939), Greek professor Gianna Angelopoulos-Daskalaki (born 1955), Greek businesswoman Giorgos Angelopoulos (born 1974), Greek businessman Jaime Angelopoulos (born 1982), Canadian sculptor Lycourgos Angelopoulos (1941–2014), director of the Greek Byzantine Choir Manolis Angelopoulos (1939–1989), Greek singer Panagiotis Angelopoulos (born 1973), Greek businessman Theo Angelopoulos (1935–2012), Greek film director Theodore Angelopoulos (born 1943), Greek businessman Vassilis Angelopoulos (born 1965), THEMIS principal investigator at the University of California's Berkeley Space Sciences Laboratory, in Berkeley, Calif.