The 1921 Ole Miss Rebels football team represented the University of Mississippi (Ole Miss) as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1921 college football season. Led by third-year head coach R. L. Sullivan, the Rebels compiled an overall record of 3–6, with a mark of 1–3 in conference play, and a loss in the Bacardi Bowl. Ole Miss played home games at Hemingway Stadium in Oxford, Mississippi.
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