Total Defence may refer to:
Defence policy Total defence, the general concept in defence policy. Total Defence (Singapore), the defence strategy introduced in Singapore in 1984. National CBRN Defence Centre (Totalförsvarets skyddscentrum), also known as the Total Defence Protection Center in Sweden.
Sports Total defense (gridiron football), gridiron football statistic, counterpart to total offense
Software CA Anti-Spyware, computer software provided by Total Defense Inc.