MOST may refer to:

Organizations MOST (Croatia), a political party in Croatia founded in 2012 Milton J. Rubenstein Museum of Science and Technology, a museum in Syracuse, New York, US Ministry of Science and Technology, a ministry or other government agency MOST (Association, Serbia) a Non-governmental Citizen's association from Serbia Music & Opera Singers Trust, an opera and classic music organisation in Australia that created the Opera Awards

Science and technology Maynard Operation Sequence Technique, a work measurement system Media Oriented Systems Transport, an electronic bus type architecture for on-board audio-visual devices, primarily in automobiles Microvariability and Oscillations of STars telescope, a stellar photometric monitoring satellite built by Canada Molonglo Observatory Synthesis Telescope, a radio telescope in Australia MOST (ATM Network) a defunct network of bank Automatic Teller Machines on the East Coast of the United States Molecular Solar Thermal System, a form of thermal energy storage

See also Most (disambiguation)