X's and O's, Exes and Ohs, Ex's and Oh's, and other variants in spelling of that phrase may refer to:

Xs and Os, another name for the game Tic-tac-toe

Music "Ex's and Oh's" (Atreyu song), 2006 "Ex's & Oh's", a 2014 song by Elle King "XXX's and OOO's (An American Girl)", a 1994 song by Trisha Yearwood

Multimedia Exes & Ohs, a 2007 Canadian/American cable TV series

See also XO (disambiguation) XOXO (disambiguation) Tic Tac Toe (disambiguation)