Cabin pressurization is a process in which conditioned air is pumped into the cabin of an aircraft or spacecraft in order to create a safe and comfortable environment for humans flying at high altitudes. For aircraft, this air is usually bled off from the gas turbine engines at the compressor stage, and for spacecraft, it is carried in high-pressure, often cryogenic, tanks. The air is cooled, humidified, and mixed with recirculated air by one or more environmental control systems before it is distributed to the cabin.

The first experimental pressurization systems saw use during the 1920s and 1930s. In the 1940s, the first commercial aircraft with a pressurized cabin entered service. The practice would become widespread a decade later, particularly with the introduction of the British de Havilland Comet jetliner in 1949. However, two catastrophic failures in 1954 temporarily grounded the Comet worldwide. These failures were investigated and found to be caused by a combination of progressive metal fatigue and aircraft skin stresses caused from pressurization. Improved testing involved multiple full-scale pressurization cycle tests of the entire fuselage in a water tank, and the key engineering principles learned were applied to the design of subsequent jet airliners.

Certain aircraft have unusual pressurization needs. For example, the supersonic airliner Concorde had a particularly high pressure differential due to flying at unusually high altitude: up to while maintaining a cabin altitude of . This increased airframe weight and necessitated the use of smaller cabin windows intended to slow the decompression rate if a depressurization event occurred.

The Aloha Airlines Flight 243 incident in 1988, involving a Boeing 737-200 that suffered catastrophic cabin failure mid-flight, was primarily caused by the aircraft's continued operation despite having accumulated more than twice the number of flight cycles that the airframe was designed to endure.

For increased passenger comfort, several modern airliners, such as the Boeing 787 Dreamliner and the Airbus A350 XWB, feature reduced operating cabin altitudes as well as greater humidity levels; the use of composite airframes has aided the adoption of such comfort-maximizing practices.

Need for cabin pressurization Pressurization becomes increasingly necessary at altitudes above above sea level to protect crew and passengers from the risk of a number of physiological problems caused by the low outside air pressure above that altitude. For private aircraft operating in the US, crew members are required to use oxygen masks if the cabin altitude (a representation of the air pressure, see below) stays above for more than 30 minutes, or if the cabin altitude reaches at any time. At altitudes above , passengers are required to be provided, but are not required to use, oxygen masks as well. On commercial aircraft, the cabin altitude must be maintained at or less. Pressurization of the cargo hold is also required to prevent damage to pressure-sensitive goods that might leak, expand, burst or be crushed on re-pressurization. The principal physiological problems are listed below.

Hypoxia The lower partial pressure of oxygen at high altitude reduces the alveolar oxygen tension in the lungs and subsequently in the brain, leading to sluggish thinking, dimmed vision, loss of consciousness, and ultimately death. In some individuals, particularly those with heart or lung disease, symptoms may begin as low as , although most passengers can tolerate altitudes of without ill effect. At this altitude, there is about 25% less oxygen than there is at sea level. – Online interactive altitude oxygen calculator Hypoxia may be addressed by the administration of supplemental oxygen, either through an oxygen mask or through a nasal cannula. Without pressurization, sufficient oxygen can be delivered up to an altitude of about . This is because a person who is used to living at sea level needs about partial oxygen pressure to function normally and that pressure can be maintained up to about by increasing the mole fraction of oxygen in the air that is being breathed. At , the ambient air pressure falls to about 0.2 bar, at which maintaining a minimum partial pressure of oxygen of 0.2 bar requires breathing 100% oxygen using an oxygen mask. Emergency oxygen supply masks in the passenger compartment of airliners do not need to be pressure-demand masks because most flights stay below . Above that altitude the partial pressure of oxygen will fall below 0.2 bar even at 100% oxygen and some degree of cabin pressurization or rapid descent will be essential to avoid the risk of hypoxia. Altitude sickness Hyperventilation, the body's most common response to hypoxia, does help to partially restore the partial pressure of oxygen in the blood, but it also causes carbon dioxide (CO2) to out-gas, raising the blood pH and inducing alkalosis. Passengers may experience fatigue, nausea, headaches, sleeplessness, and (on extended flights) even pulmonary edema. These are the same symptoms that mountain climbers experience, but the limited duration of powered flight makes the development of pulmonary edema unlikely. Altitude sickness may be controlled by a full pressure suit with helmet and faceplate, which completely envelops the body in a pressurized environment; however, this is impractical for commercial passengers. Decompression sickness The low partial pressure of gases, principally nitrogen (N2) but including all other gases, may cause dissolved gases in the bloodstream to precipitate out, resulting in gas embolism, or bubbles in the bloodstream. The mechanism is the same as that of compressed-air divers on ascent from depth. Symptoms may include the early symptoms of "the bends"—tiredness, forgetfulness, headache, stroke, thrombosis, and subcutaneous itching—but rarely the full symptoms thereof. Decompression sickness may also be controlled by a full-pressure suit as for altitude sickness. Barotrauma As the aircraft climbs or descends, passengers may experience discomfort or acute pain as gases trapped within their bodies expand or contract. The most common problems occur with air trapped in the middle ear (aerotitis) or paranasal sinuses by a blocked Eustachian tube or sinuses. Pain may also be experienced in the gastrointestinal tract or even the teeth (barodontalgia). Usually these are not severe enough to cause actual trauma but can result in soreness in the ear that persists after the flight and can exacerbate or precipitate pre-existing medical conditions, such as pneumothorax.

Cabin altitude

The pressure inside the cabin is technically referred to as the equivalent effective cabin altitude or more commonly as the cabin altitude. This is defined as the equivalent altitude above mean sea level having the same atmospheric pressure according to a standard atmospheric model such as the International Standard Atmosphere. Thus a cabin altitude of zero would have the pressure found at mean sea level, which is taken to be .

Aircraft In airliners, cabin altitude during flight is kept above sea level in order to reduce stress on the pressurized part of the fuselage; this stress is proportional to the difference in pressure inside and outside the cabin. In a typical commercial passenger flight, the cabin altitude is programmed to rise gradually from the altitude of the airport of origin to a regulatory maximum of . This cabin altitude is maintained while the aircraft is cruising at its maximum altitude and then reduced gradually during descent until the cabin pressure matches the ambient air pressure at the destination.

Keeping the cabin altitude below generally prevents significant hypoxia, altitude sickness, decompression sickness, and barotrauma. Federal Aviation Administration (FAA) regulations in the U.S. mandate that under normal operating conditions, the cabin altitude may not exceed this limit at the maximum operating altitude of the aircraft. This mandatory maximum cabin altitude does not eliminate all physiological problems; passengers with conditions such as pneumothorax are advised not to fly until fully healed, and people suffering from a cold or other infection may still experience pain in the ears and sinuses. The rate of change of cabin altitude strongly affects comfort as humans are sensitive to pressure changes in the inner ear and sinuses and this has to be managed carefully. Scuba divers flying within the "no fly" period after a dive are at risk of decompression sickness because the accumulated nitrogen in their bodies can form bubbles when exposed to reduced cabin pressure.

The cabin altitude of the Boeing 767 is typically about when cruising at . This is typical for older jet airliners. A design goal for many, but not all, newer aircraft is to provide a lower cabin altitude than older designs. This can be beneficial for passenger comfort. For example, the Bombardier Global Express business jet can provide a cabin altitude of when cruising at . The Emivest SJ30 business jet can provide a sea-level cabin altitude when cruising at .Flight Test: Emivest SJ30 – Long-range rocket Retrieved 27 September 2012.SJ30-2, United States of America Retrieved 27 September 2012. One study of eight flights in Airbus A380 aircraft found a median cabin pressure altitude of , and 65 flights in Boeing 747-400 aircraft found a median cabin pressure altitude of .

Before 1996, approximately 6,000 large commercial transport airplanes were assigned a type certificate to fly up to without having to meet high-altitude special conditions. In 1996, the FAA adopted Amendment 25–87, which imposed additional high-altitude cabin pressure specifications for new-type aircraft designs. Aircraft certified to operate above "must be designed so that occupants will not be exposed to cabin pressure altitudes in excess of after any probable failure condition in the pressurization system". In the event of a decompression that results from "any failure condition not shown to be extremely improbable", the plane must be designed such that occupants will not be exposed to a cabin altitude exceeding for more than 2 minutes, nor to an altitude exceeding at any time. In practice, that new Federal Aviation Regulations amendment imposes an operational ceiling of on the majority of newly designed commercial aircraft. Aircraft manufacturers can apply for a relaxation of this rule if the circumstances warrant it. In 2004, Airbus acquired an FAA exemption to allow the cabin altitude of the A380 to reach in the event of a decompression incident and to exceed for one minute. This allows the A380 to operate at a higher altitude than other newly designed civilian aircraft.

Spacecraft Russian engineers used an air-like nitrogen/oxygen mixture, kept at a cabin altitude near zero at all times, in their 1961 Vostok, 1964 Voskhod, and 1967 to present Soyuz spacecraft. This requires a heavier space vehicle design, because the spacecraft cabin structure must withstand the stress of 14.7 pounds per square inch (1 atm, 1.01 bar) against the vacuum of space, and also because an inert nitrogen mass must be carried. Care must also be taken to avoid decompression sickness when cosmonauts perform extravehicular activity, as current soft space suits are pressurized with pure oxygen at relatively low pressure in order to provide reasonable flexibility.Gatland, p. 134