HPB may refer to:
Half Price Books, an American book retailer Harvard Papers in Botany, a scientific journal Health Promotion Board, a statutory board in Singapore for health promotion and disease prevention Helena Petrovna Blavatsky (1831–1891), theosophist, writer and traveler Hooper Bay Airport, in Alaska, United States (by IATA and FAA LID code) Hrvatska poštanska banka, largest Croatian-owned bank HPB (journal), journal of the International Hepato-Pancreato-Biliary Association Hexaphenylbenzene