SPO may refer to:
Politics Serbian Renewal Movement (, SPO), a political party in Serbia Socialist Party of Ontario, Canada Strengthening Participatory Organization, a rights-based organization in Pakistan Social Democratic Party of Austria (, SPÖ), political party in Austria Party of Civic Rights (, SPO), political party in the Czech Republic
Technology Secondary phosphine oxide, a class of organophosphorus compounds SharePoint Online
Other Saint Paul's Outreach, a Catholic missionary organization SPO:), a Lithuanian sports magazine SPO Rouen Basket, a basketball club in Rouen, France Scholarly Publishing Office, University of Michigan University Library Seoul Philharmonic Orchestra, a South Korean orchestra based in Seoul Strong Pareto optimum, in economics Supreme Prosecutors' Office of the Republic of Korea Erik Spoelstra, head coach of the Miami Heat Sankt Peter-Ording, a tourist town in northern Germany
See also Spo11, a protein used in a complex along with Mre11 and Rad50 during meiotic recombination SPOC (disambiguation)