Leatherwood is a surname. Notable people with the surname include:
Alex Leatherwood (born 1998), American football player Bryce Leatherwood (born 2000), American country singer Elmer O. Leatherwood (1872–1929), American politician Gavin Leatherwood (born 1994), American actor and singer Frank Leatherwood (born 1977), American football player Lillie Leatherwood (born 1964), American athlete Ray Leatherwood (1914–1996), American jazz double-bassist Robert N. Leatherwood (1844–1920), American businessman Tom Leatherwood (born 1956), American politician