Mark Nye Willis (born August 1, 1959) is an American politician. He is a member of the South Carolina House of Representatives from the 16th District, serving since 2008. He is a member of the Republican party.

Willis is Chair of the House Interstate Cooperation Committee."House Standing Committees". South Carolina Legislature. December 7, 2022. Retrieved December 18, 2022.

In 2023, Willis was briefly among the Republican co-sponsors of the South Carolina Prenatal Equal Protection Act of 2023, which would make women who had abortions eligible for the death penalty; he later withdrew his sponsorship.

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