The Muisca are an indigenous people in Colombia.

Muisca may also refer to:

Muisca Confederations, the former chiefdoms formed by the Muisca Chibcha language, the language of the Muisca, also called "Muisca", "Mosca" or "Muysccubun" Muisca (beetle), a checkered beetle genus Alabagrus muisca, a species of wasp of the genus Alabagrus Atelopus muisca, a species of toad of the genus Atelopus Brachygasterina muisca, a species of fly of the genus Brachygasterina Euryomma muisca, a species of fly of the genus Euryomma