William Sprague may refer to: William Sprague (1609–1675), original American settler William Buell Sprague (1795–1876), American clergyman and compiler of Annals of the American Pulpit William Sprague III (1799–1856), American politician from Rhode Island, uncle of William Sprague IV William Sprague (Michigan politician) (1809–1868), politician from Michigan William P. Sprague (1827–1899), politician from Ohio William Sprague IV (1830–1915), politician from Rhode Island, nephew of William Sprague III William George Robert Sprague (1863–1933), London theatre designer William C. Sprague (1860–1922), founder of The American Boy magazine
See also Sprague (surname)