Handedness is a human attribute reflecting the unequal distribution of fine motor skill between the left and right hands.

Handedness may also refer to:

Chirality, Greek for handedness, used to describe similar concepts in other fields: Chirality (chemistry), a property of molecules having a non-superimposable mirror image Chirality (electromagnetism), an electromagnetic propagation in chiral media Chirality (mathematics), the property of a figure not being identical to its mirror image Chirality (physics), when a phenomenon is not identical to its mirror image Sinistral and dextral, terms in biology and geology Orientation (vector space), an asymmetry that makes a reflection impossible to replicate by means of a simple rotation Handedness of a helix, a spiral structure Handedness of screw threads, springs, or propellers, in mechanics and engineering