Rhein-Selz is a Verbandsgemeinde ("collective municipality") in the district Mainz-Bingen in Rhineland-Palatinate, Germany. It takes its name from the two rivers Rhine and Selz. It is situated on the left bank of the Rhine, south of Mainz. It was formed on 1 July 2014 by the merger of the former Verbandsgemeinden Nierstein-Oppenheim and Guntersblum. Its seat is in Oppenheim.

The Verbandsgemeinde consists of the following Ortsgemeinden ("local municipalities"):

Dalheim Dexheim Dienheim Dolgesheim Dorn-Dürkheim Eimsheim Friesenheim Guntersblum Hahnheim Hillesheim Köngernheim Ludwigshöhe Mommenheim Nierstein Oppenheim Selzen Uelversheim Undenheim Weinolsheim Wintersheim

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