The following list shows the rates of adverse symptoms seen in people taking venlafaxine.

Very common (>10% incidence) Headache — an often transient side effect that is common to most serotonin reuptake inhibitors and that most often occurs at the beginning of therapy or after a dose escalation. Nausea — an adverse effect that is more common with venlafaxine than with the SSRIs. Usually transient and less severe in those receiving the extended release formulations. Insomnia Asthenia (weakness) Dizziness Ejaculation disorder — sexual side effects can be seen with virtually any antidepressant, especially those that inhibit the reuptake of serotonin (including venlafaxine). Somnolence Dry mouth Sweating Withdrawal

Common (1–10% incidence)

Constipation Nervousness Abnormal vision Anorgasmia Hypertension Impotence Paresthesia Tremor Vasodilation Vomiting Weight loss Chills Palpitations Confusion Depersonalization Night sweats Menstrual disorders associated with increased bleeding or increased irregular bleeding (e.g. menorrhagia, metrorrhagia) Urinary frequency increased Abnormal dreams Decreased libido Increased muscle tonus Yawning Abnormality of accommodation Abnormal ejaculation/orgasm (males) Urinary hesitancy Serum cholesterol increased (especially when treatment is prolonged and it may be dose-dependent)

Uncommon (0.1-1% incidence)

Face edema (Swelling) Intentional injury (Self-injury) Malaise Moniliasis (Candidiasis/Thrush) Neck stiffness Pelvic pain Photosensitivity reaction Suicide attempt Withdrawal syndrome Hypotension (Low blood pressure) Postural hypotension Syncope (Fainting) Tachycardia (High heart rate) Bruxism (Teeth grinding) Ecchymosis (Bruising) Mucous membrane bleeding Gastrointestinal bleeding Abnormal liver function tests Hyponatraemia (Low blood sodium) Weight gain Apathy Hallucinations Myoclonus (Twitching or Muscle spasm) Rash Abnormal orgasm (females) Urinary retention (Inability to pass urine) Angioedema (Swelling of skin or mucous membranes) Agitation Impaired coordination & balance Alopecia (Hair loss) Tinnitus (Ringing in the ears, Hearing sounds) Proteinuria (Protein in urine)

Rare (0.01–0.1% incidence) Syndrome of inappropriate antidiuretic hormone secretion (SIADH) Thrombocytopenia Prolonged bleeding time Seizures Mania Neuroleptic malignant syndrome (NMS) Serotonin syndrome Akathisia/psychomotor restlessness Urinary incontinence

Very rare (<0.01% incidence)

Anaphylaxis QT prolongation Ventricular fibrillation Ventricular tachycardia (including torsades de pointes) Pancreatitis Blood dyscrasias (including agranulocytosis, aplastic anaemia, neutropenia and pancytopenia) Elevated serum prolactin Delirium Extrapyramidal reactions (including dystonia and dyskinesia) Tardive dyskinesia Pulmonary eosinophilia Erythema multiforme Stevens–Johnson syndrome Pruritus Urticaria Toxic epidermal necrolysis Angle closure glaucoma

References