Most is a surname. Some notable people with the surname include:

Deforrest Most (1917–2006), American gymnast Don Most (born 1953), American actor Doug Most (born 1968), editor of The Boston Globe Magazine Glenn W. Most (born 1952), American classicist and comparatist Jeff Most (born 1960), American film producer Johann Most (1846–1906), German-American anarchist and orator Johnny Most (1923–1993), American sports announcer Liza van der Most (born 1993), Dutch footballer Mickie Most (1938–2003), English record producer Sam Most (1930–2013), Los Angeles–based jazz flautist and tenor saxophonist

See also Most (disambiguation)