Zuffi is an Italian surname. Notable people with the surname include:
Ambrogio Zuffi (1833–1922), Italian sculptor Dario Zuffi (born 1964), Swiss footballer and coach Giulia Francesca Zuffi ( 1678–1685), Italian opera singer Luca Zuffi (born 1990), Swiss footballer, son of Dario Piero Zuffi (1919–2006), Italian set designer and painter