List of adverse effects of nilotinib

This is a list of adverse effects of the anti-cancer drug nilotinib, sorted by frequency of occurrence.

Very common Very common (>10% incidence) adverse effects include:

Headache Nausea Hypophosphataemia Hyperbilirubinaemia Alanine aminotransferase (ALT) increased Aspartate aminotransferase increased Lipase increased Rash Itchiness Hair loss Dry skin Muscle aches Fatigue

Common Common (1–10% incidence) adverse effects include:

Constipation Diarrhoea Vomiting Upper abdominal pain Indigestion Joint pain Muscle spasms Pain in extremities Asthenia Peripheral oedema Folliculitis Upper respiratory tract infection (including pharyngitis, nasopharyngitis, rhinitis) Skin papilloma Eosinophilia Lymphopenia Insomnia Anxiety Depression Diabetes mellitus Hypercholesterolaemia Hyperlipidaemia Hypertriglyceridaemia Hyperglycaemia Loss of appetite Dizziness Hypoaesthesia Peripheral neuropathy Eye pruritus Conjunctivitis Dry eye (including xerophthalmia) Vertigo Flushing Hypertension Angina pectoris Arrhythmia (including atrioventricular block, tachycardia, atrial fibrillation, ventricular extrasystoles, bradycardia) QT interval prolonged Palpitations Cough Dyspnoea Abdominal distension Abdominal discomfort Taste changes Flatulence Abnormal liver function Bone pain Back pain Erythema Hyperhidrosis Contusion Acne Dermatitis (including allergic, exfoliative and acneiform) Night sweats Fever without an infectious cause Chest pain (including non-cardiac chest pain) Chest discomfort Decreased haemoglobin Increased blood amylase Increased blood alkaline phosphatase Gamma-glutamyltransferase increased Weight increased Increased blood insulin Increased lipoprotein (including very low density and high density)

Uncommon Uncommon (0.1–1% incidence) adverse effects include:

Arteriosclerosis Bone marrow suppression Both increases and decreases of potassium levels Body temperature change sensation (both hot and cold) Chills Cognitive deficits Conjunctival bleeding and redness Cyanosis Dental sensitivity to pain Bleeding into the lungs Increased blood cholesterol and lipid levels Dystonia Erectile dysfunction Eyelid swelling Flank pain Gastritis Gout Decreased calcium levels Jaundice Malaise Migraine Muscle pain and weakness Pancreatitis Paraesthesia Peripheral arterial occlusive disease Photopsia Pleural effusion Skin eruptions Skin pain Decreased globulins

References