Sarafian or Sarafyan () is an Armenian surname. It is patronymic from Arabic saraf, ‘money changer’, ‘banker’. Notable people with the surname include:
Ara Sarafian, British historian Asatour Sarafian, known as Oscar H. Banker (1895–1979), Ottoman Empire-born Armenian-American inventor Barbara Sarafian (born 1968), Belgian actress Bruce Sarafian (born 1966), American juggler Daniel Sarafian (born 1982), Brazilian-Armenian martial artist Deran Sarafian (born 1961), American actor, film and television director Katherine Sarafian (born 1970), American film producer at Pixar Animation Studios Nigoghos Sarafian (1905–1973), Armenian writer Richard C. Sarafian (1930–2013), American actor, film and television director Sue Sarafian Jehl (1917–1997), American military personnel, one of the three personal secretaries to General Dwight Eisenhower during World War II Tedi Sarafian, American screenwriter Angela Sarafyan, Armenian-American actress