Gambetta is a surname. Notable people with the surname include:
Beppe Gambetta (b. 1955), Italian musician Diego Gambetta (b. 1952), Italian sociologist Gianmarco Gambetta (b. 1991), Peruvian footballer Léon Gambetta (1838–1882), French statesman Schubert Gambetta (1920–1991), Uruguayan footballer Jay Gambetta (b. 1979), American Physicist