San Tomé may refer to:
Rotonda di San Tomè, a church in northern Italy San Tomé, Venezuela, a town in Anzoátegui, Venezuela San Tomé de Angostura, one of the original names of the city Ciudad Bolivar, Venezuela São Tomé and Príncipe, an island nation in the Gulf of Guinea São Tomé Island, one of two islands and provinces in nation of São Tomé and Príncipe São Tomé, the capital city of the island and province of São Tomé