Glucosyl-3-phosphoglycerate phosphatase (EC 3.1.3.85, GpgP protein) is an enzyme with systematic name α-D-glucosyl-3-phospho-D-glycerate phosphohydrolase. It catalyses a chemical reaction which removes a phosphate group (Pi) by hydrolysis:
This is the second step in the biosynthesis of 2-O-(α-D-glucopyranosyl)-D-glyceric acid, and the enzyme has been characterised from Methanococcoides burtonii and Persephonella marina. The first step catalysed by glucosyl-3-phosphoglycerate synthase produces the phosphoglycerate derivative by adding a glucose unit from UDP-glucose. This pair of enzymes are also present in Mycobacterium tuberculosis and the product is incorporated into methylglucose lipopolysaccharides.
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