Penhaligon is a surname originating in Cornwall, Great Britain. Notable people with the surname include:
William Penhaligon (1837–1902), Cornish barber and perfumer, founder of Penhaligon's David Penhaligon (1944–1986), Liberal MP from Cornwall Dame Annette Penhaligon (born 1946), British politician Susan Penhaligon (born 1949), British actress
Other Penhaligon's, English perfume house The Penhaligon Trilogy, a series set in the Mystara realm of Dungeons & Dragons Penhaligon, a type of shot used in the game of Tiddlywinks