Brescia or da Brescia is a surname derived from the city of Brescia in Italy. Notable people with the surname include:
Alfonso Brescia (1930–2001), film director Domenico Brescia (1866–1939), composer Fortunato Brescia Tassano (d. 1951), Italian-born Peruvian businessman Georgia Brescia (born 1996), Italian tennis player Giovanni Antonio da Brescia, Italian painter Giovanni Maria da Brescia, Italian painter Jason Michael Brescia (born 1986), American comedy writer-director Justin Brescia (born 1982), American actor Leonardo Brescia (1520–1582), Italian painter Lisa Brescia (born 1970), American actress Mario Brescia Cafferata (1929–2013), Peruvian billionaire businessman Moretto da Brescia (c. 1498–1554), Italian painter Pedro Brescia Cafferata (1921–2014), Peruvian businessman Rosa Brescia Cafferata (born c. 1926), Peruvian billionaire heiress and philanthropist