TRNA (cytidine32/uridine32-2'-O)-methyltransferase (, YfhQ, tRNA:Cm32/Um32 methyltransferase, TrMet(Xm32), TrmJ) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine32/uridine32-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction
(1) S-adenosyl-L-methionine + cytidine32 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA (2) S-adenosyl-L-methionine + uridine32 in tRNA S-adenosyl-L-homocysteine + 2'-O-methyluridine32 in tRNA
In Escherichia coli YfhQ is the only methyltransferase responsible for the formation of 2'-O-methylcytidine32 in tRNA.
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