Ketosteroid monooxygenase (, steroid-ketone monooxygenase, progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing), 17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving), androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)) is an enzyme with systematic name ketosteroid, NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing). This enzyme catalyses the following chemical reaction
ketosteroid + NADPH + H+ + O2 steroid ester/lactone + NADP+ + H2O (general reaction) (1) progesterone + NADPH + H+ + O2 testosterone acetate + NADP+ + H2O (2) androstenedione + NADPH + H+ + O2 testololactone + NADP+ + H2O (3) 17alpha-hydroxyprogesterone + NADPH + H+ + O2 androstenedione + acetate + NADP+ + H2O
Ketosteroid monooxygenase is a single FAD-containing enzyme that catalyses three types of monooxygenase reaction.
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