Markussen is a surname. Notable people with the surname include:
John Arne Markussen (born 1953), Norwegian newspaper editor Jørgen Markussen (born 1943), Danish footballer Niels Markussen (1934–2008), Danish sailor Nikolaj Markussen (born 1988), Danish handball player Rudy Markussen (born 1977), Danish boxer Toralv Kollin Markussen (1895–1973), Norwegian politician