The 1945–46 Macedonian Republic League was the second since its establishment. Pobeda Skopje (a one of two forerunners of FK Vardar) won their first championship title.
Participating teams Club City FD Rabotnički Skopje OFD Makedonija Skopje FD Pelister Bitola FD Kumanovo Kumanovo ZFD Pobeda Skopje FD Goce Delčev Prilep
Final table
External links SportSport.ba Football Federation of Macedonia