Botryococcus squalene synthase (, SSL-2 (gene)) is an enzyme with systematic name squalene:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction

squalene + diphosphate + NADP+ presqualene diphosphate + NADPH + H+

This enzyme is isolated from the green alga Botryococcus braunii BOT22.

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