Matthewson is a patronymic surname, meaning "son of Matthew". Notable people with the surname include:

Bob Matthewson (died 2000), English footballer and referee Clive Matthewson (born 1944), New Zealand politician Dale Matthewson (1923–1984), American baseball player Reg Matthewson (1939–2016), English footballer Trevor Matthewson (born 1963), English footballer

See also