Purple Heart Highway may refer to:
Des Moines Bypass Guam Highway 8 Interstate 11 Interstate 20, from Interstate 285 to U.S. Route 441 Interstate 76, from Interstate 71 to Interstate 80 Interstate 180 (Nebraska) Pennsylvania Route 5 Pennsylvania Route 45 U.S. Route 5, from East Hartford to East Windsor-Enfield U.S. Route 171