Brush Creek may refer to the following places in the United States:

California Brush Creek (Sonoma County, California)

Colorado Brush Creek, Colorado, an unincorporated community in northern Custer County, Colorado and its namesake river, a tributary of Texas Creek

Iowa Brush Creek (White Breast Creek), a stream in the Des Moines River catchment

Minnesota Brush Creek Township, Faribault County, Minnesota Brush Creek, Minnesota, an unincorporated community

Missouri Brush Creek, Missouri, an unincorporated community Brush Creek (Blue River tributary) Brush Creek (Bourbeuse River tributary) Brush Creek (Bryant Creek tributary) Brush Creek (Fox River tributary) Brush Creek (Gasconade River tributary) Brush Creek (Lamine River tributary) Brush Creek (Missouri River tributary) Brush Creek (North Fork Salt River tributary) Brush Creek (Osage Fork Gasconade River tributary) Brush Creek (Sac River tributary) Brush Creek (South Moreau Creek tributary) Brush Creek (Thompson River tributary)

Montana Brush Creek (Montana), a stream in Flathead County

Nebraska Brush Creek (Niobrara River tributary), a stream in Holt County, Nebraska

North Carolina Brush Creek (Reedy Fork tributary), a stream in Guilford County Brush Creek (Deep River tributary), a stream in Randolph and Chatham Counties

Ohio Brush Creek Township, Ohio (disambiguation), four different townships Ohio Brush Creek

Oklahoma Brush Creek, Oklahoma, a census-designated place

Oregon Brush Creek (Curry County, Oregon)

Pennsylvania Brush Creek (Connoquenessing Creek tributary) Brush Creek (Raystown Branch Juniata River tributary) Brush Creek (Shaffer Creek tributary) Brush Creek (Wills Creek tributary) Brush Creek Township, Fulton County, Pennsylvania

Tennessee Brush Creek, Sequatchie County, Tennessee Brush Creek, Smith County, Tennessee Brush Creek, Williamson County, Tennessee

Utah Brush Creek (Utah), a tributary of the Green River

Virginia Brush Creek (Banister River tributary), a stream in Halifax County, Virginia

West Virginia Brush Creek, West Virginia, an unincorporated community in Boone County Brush Creek (Boone County), a stream Brush Creek (Cabell County), a stream Brush Creek (Kanawha County), a stream Brush Creek (Mercer County), a tributary of the Bluestone National Scenic River Brush Creek (Monroe County), a stream Brush Creek (Wayne County), a stream

Wyoming Brush Creek (Medicine Bow National Forest), site of Brush Creek Work Center