De Meester is a surname. Notable people with the surname include:
Hans De Meester (born 1970), Belgian cyclist Luca de Meester (born 2004), German footballer Marie Louise De Meester (1857–1928), Belgian missionary and founder of the Missionary Sisters of the Immaculate Heart of Mary Sam de Meester (born 1982), footballer Theo de Meester (1851–1919), Dutch politician (prime minister) and economist De Meester cabinet