Van Hamme or van Hamme is a Dutch-language surname. Notable people with the surname include:
Alexis Van Hamme (1818–1875), Belgian painter Jean Van Hamme (born 1939), Belgian writer Joost van Hamme (1629/30 - after 1657), Flemish painter Thomas Van Hamme (born 1969), Belgian television presenter Victor Van Hamme (1897–?), Belgian weightlifter