S-Glutathionylation is the posttranslational modification of protein cysteine residues by the addition of glutathione, the most abundant and important low-molecular-mass thiol within most cell types.
Protein S-glutathionylation is involved in the following: oxidative stress nitrosative stress preventing irreversible oxidation of protein thiols control of cell-signalling pathways by modulating protein function
Protein S-glutathionylation, which is reversible, entails formation of a mixed disulfide. It is one of a host of reactions of the cysteine residues.
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