R80 or R-80 may refer to:
Aircraft R80 (airship), a British rigid airship Bushcaddy R-80, a Canadian ultralight and light-sport aircraft Fisher R-80 Tiger Moth, a Canadian kit biplane RAI R-80, an Indonesian regional turboprop airliner Romano R.80, a French aerobatic biplane
Other uses R80 (South Africa), a road Colt R80, a machine gun Proteinuria R80 series of preferred numbers Toyota Noah (R80), a minivan R80, a Ferris wheel designed by Ronald Bussink