The first sequences of keratins revealed that keratins could be grouped into two categories based on their sequence homologies. These two groups of keratins were named as type I and type II keratins. These two categories also represent the first two categories of the superfamily of intermediate filament proteins.
Keratins in this table are classified in the first two columns according to the nomenclature established in 2006. Other names previously used are listed in columns 3 and 4.
Type I keratins
Human epithelial keratins
Protein name Gene name Other protein name Other gene name K9 KRT9 Ka9 K10 KRT10 Ka10 K12 KRT12 Ka12 K13 KRT13 Ka13 K14 KRT14 Ka14 K15 KRT15 Ka15 K16 KRT16 Ka16 K17 KRT17 Ka17 K18 KRT18 Ka18 K19 KRT19 Ka19 K20 KRT20 Ka20 K23 KRT23 Ka23 K24 KRT24 Ka24 K25 KRT25 Ka38, K25irs1, K10C, hIRSa1 KRT25A K26 KRT26 Ka39, K25irs2, K10D K27 KRT27 Ka40, K25irs3, K10B, hIRSa3.1 K28 KRT28 Ka41, K25irs4, hIRSa2
Human hair keratins
Protein name Gene name Other protein name Other gene name K31 KRT31 Ka25, Ha1 KRTHA1 K32 KRT32 Ka26, Ha2 KRTHA2 K33a KRT33A Ka27, Ha3-I KRTHA3A K33b KRT33B Ka28, Ha3-II KRTHA3B K34 KRT34 Ka29, Ha4 KRTHA4 K35 KRT35 Ka30, Ha5 KRTHA5 K36 KRT36 Ka31, Ha6 KRTHA6 K37 KRT37 Ka32, Ha7 KRTHA7 K38 KRT38 Ka33, Ha8 KRTHA8 K39 KRT39 Ka35 K40 KRT40 Ka36
Nonhuman hair/epithelial keratins
Protein name Gene name Other protein name Other gene name K41 chimp, gorilla, dog KRT41 chimp, gorilla, dog; KRT41P man, horse φhHaA, Ka34P man K42 mouse, rat KRT42 mouse, rat; KRT42P man Ka22 mouse, rat, K17n mouse, rat
Human keratin pseudogenes
Protein name Gene name Other protein name Other gene name KRT221P φhHaB KRT222P φKRTI, Ka21P KRT223P φKRTJ, Ka37P
Type II keratins
Human epithelial keratin
Protein name Gene name Other protein name Other gene name K1 KRT1 Kb1 K2 KRT2 Kb2, K2e KRT2A K3 KRT3 Kb3 K4 KRT4 Kb4 K5 KRT5 Kb5 K6a KRT6A Kb6 K6b KRT6B Kb10 K7 KRT7 Kb7 K8 KRT8 Kb8 K71 KRT71 Kb34, K6irs1 K72 KRT72 Kb35, K6irs2 K73 KRT73 Kb36, K6irs3 K74 KRT74 Kb37, K6irs4 K75 KRT75 Kb18, K6hf K76 KRT76 Kb9, K2p KRT2B K77 KRT77 Kb39, K1b K78 KRT78 Kb40, K5b K79 KRT79 Kb38, K6I K80 KRT80 Kb20
Human hair keratins
Protein name Gene name Other protein name Other gene name K81 KRT81 Kb21, Hb1, K2.9 KRTHB1 K82 KRT82 Kb22, Hb2 KRTHB2 K83 KRT83 Kb23, Hb3, K2.10 KRTHB3 K84 KRT84 Kb24, Hb4 KRTHB4 K85 KRT85 Kb25, Hb5, K2.12 KRTHB5 K86 KRT86 Kb26, Hb6, K2.11 KRTHB6
Human keratin pseudogenes
Protein name Gene name Other protein name Other gene name KRT121P φhHbD, Kb31P KRT122P φhHbC, Kb30P KRT123P φhHbB, Kb29P KRT124P φhHbA, Kb28P KRT125P φKRTH KRT126P φKRTG, Kb19P KRT127P φKRTF KRT128P φKRTE
See also
Keratins Skin Epidermis
References