An avunculate marriage (or uncle/aunt-niece/nephew marriage) is a marriage with a parent's sibling or with one's sibling's child—i.e., an uncle or aunt marrying their niece or nephew. Such a marriage may occur between biological (consanguine) relatives or between persons related by marriage (affinity). In some countries, avunculate marriages are prohibited by law, while in others marriages between such biological relatives are both legal and common, though now far less common.

If the partners in an avunculate marriage are biologically related, they normally have the same genetic relationship as half-siblings, or a grandparent and grandchild—that is they share approximately 25% of their genetic material. (They are therefore more closely related than partners in a marriage between first cousins or between granduncle/grandaunt and grandniece/grandnephew, in which on average the members share 12.5% of inherited genetic material, but less than that of a marriage between, for instance, three-quarter siblings, in which the partners share 37.5% of their inherited genetic material.)

Avunculate marriage is permitted in Denmark, Germany,German Civil Code (Section 1307) Switzerland, Czech Republic, Chile, Argentina, Australia, Canada, Finland, Macau, Thailand,Title I – Marriage (article 1450) Malaysia,Law Reform (Marriage and Divorce) Act 1976 (for Hindus only) The Netherlands, Cuba and Russia. In the United States it is permitted in some circumstances in two states. In New York a marriage between a woman and her mother's half-brother was upheld by the New York Court of Appeals. In Rhode Island there is an exception to the general prohibition against "kindred marriages" for Jewish marriages allowed by that religion. It is not permitted in New Zealand, Brazil,Presidency of the Republic Civil House Deputy Director for Legal Affairs (article 1521, IV) Ireland, Spain,Spanish civil code (article 47) Portugal,Iniciar o processo de casamento Italy, Hungary, Peru, Mexico, Japan,Civil Code (Part IV and Part V) (article 734) Hong Kong,Cap. 181 Marriage Ordinance (Prohibited Degrees of Relationship Referred to in Paragraph 2 of Part 1) Singapore,Civil marriage process or the United Kingdom (first cousin marriage and granduncle/grandaunt-grandniece/grandnephew marriage are permitted in these countries). In France,Civil Code (article 162) and Indonesia,Indonesian Civil Code (article 31) avunculate marriage is under permission only.

List of historical avunculate marriages Ankhesenpepi II and her nephew Merenre Nemtyemsaf Perictione and her uncle, Pyrilampes Nahor, son of Terah and his niece, Milcah Jochebed and her nephew, Amram Ahmose I and his half-niece, Ahmose-Sitkamose Thutmose I and his half-aunt, Mutnofret Smenkhkare and his niece, Meritaten Pepi II Neferkare and his aunt, Neith Pinedjem I and his half-aunt, Duathathor-Henuttawy Menkheperre and his niece, Istemkheb Shabaka and his aunt, Qalhata Leonidas, King of Sparta and his half-niece, Gorgo Arybbas of Epirus and his niece, Troas Alexander I of Epirus and his niece Cleopatra of Macedon Lucius Tarquinius Superbus and his brother Arruns Tarquinius respectively married sisters Tullia Major and Tullia Minor, who may have been their nieces. Superbus and Tullia Minor later disposed of their original spouses and married each other. Cyrus the Great and his aunt Amytis of Media Herod the Great married an unnamed niece. Salome I and her uncle Joseph Antipater II and his half-niece, Mariamne III, who was possibly later married to another half-uncle Herod Archelaus. Herod Antipas, Tetrarch of Galilee and Perea and his half-niece Herodias. Herodias was previously married to her other half-uncle Herod II. Salome, the daughter of Herod II and Herodias, married Philip the Tetrarch, who was both her half-uncle and half-granduncle. Herod of Chalcis and his niece, Berenice Philip III of Macedon and his half-niece, Eurydice II of Macedon Mithridates III of Pontus and his grand-niece, Laodice Seleucus II Callinicus and his aunt Laodice II Antigonus II Gonatas and his niece Phila Demetrius II Aetolicus and his half-aunt Stratonice of Macedon Antiochus X Eusebes and his possible half-aunt Cleopatra Selene of Syria Ptolemy VIII Physcon and his niece Cleopatra III of Egypt Ptolemy X Alexander I and his niece Berenice III of Egypt Ptolemy XII Auletes and his half-niece Cleopatra V Emperor Hui of Han and his niece Empress Zhang Yan (192 BC) Sun Xiu and his niece Empress Zhu Gwangjong of Goryeo and his half-niece Lady Gyeonghwa Injong of Goryeo and his aunt, Princess Yeondeok and Princess Bokchang Roman Emperor Claudius and his niece Agrippina the Younger (49) Tiberius Claudius Atticus Herodes and his niece Vibullia Alcia Agrippina Byzantine Emperor Heraclius and his niece Martina (c. 613) Emperor Kōan and his niece Oshihime Yamato Takeru and his aunt Futaji Irihime Emperor Kinmei and his half-niece, Ishi-Hime Emperor Jomei and his niece Empress Kōgyoku, and his aunt Princess Tame Emperor Kōtoku and his niece Princess Hashihito Emperor Tenji and his niece Yamato Hime no Ōkimi Emperor Tenmu and his nieces Empress Jitō, Princess Ōta, Princess Ōe, and Princess Niitabe Prince Kusakabe and his aunt Empress Genmei Prince Ōtsu and his half-aunt Princess Yamanobe Emperor Shōmu and his aunt Empress Kōmyō Musa ibn Musa, Wali of Zaragoza and Governor of Upper March and his half-niece Assona Íñiguez Emperor Junna and his niece Princess Seishi Prince Abo and his half-aunt Princess Ito Emperor Montoku and his half-aunt Fujiwara no Furuko Emperor Daigo and his aunt Princess Ishi and his half-aunt Minamoto no Washi Emperor Suzaku and his niece Princess Hiroko Emperor En'yū and his niece Princess Sonshi Emperor Sanjō and his half-aunt Fujiwara no Yasuko Emperor Go-Ichijō and his aunt Fujiwara no Ishi Emperor Go-Suzaku and his aunt Fujiwara no Yoshiko Emperor Go-Suzaku and his niece Fujiwara no Genshi Emperor Horikawa and his half-aunt Princess Tokushi Emperor Nijō and his half-aunt Princess Yoshiko Emperor Go-Fukakusa and his aunt Fujiwara no Kimiko Emperor Fushimi and his aunt Tōin Sueko Emperor Go-Daigo and his half-aunt Princess Kenshi Anjong of Goryeo and his half-niece Queen Heonjeong Ralph I, Count of Vermandois and his half-niece Laurette of Flanders (1152) Amaury I, Lord of Craon and his half-grandniece, Jeanne des Roches, Dame of Sablé (1212) Alfonso X of Castile had a concubinage with his paternal half-aunt Maria Alfonso de Leon Rupert I, Elector Palatine and his great-grandniece Beatrix of Berg (1385) John, Constable of Portugal and his half-niece, Isabel of Barcelos (1424) Alvaro de Zuñiga, third Duke of Bejar and his niece Leonor Pimentel y Zúñiga, Afonso V of Portugal and his niece, Joanna of Castile (1475) Jacques of Savoy, Count of Romont and his niece, Marie of Luxembourg, Countess of Vendôme (1484) Joanna of Naples and her half-nephew, King Ferdinand II of Naples (1496) Ferdinand II of Aragon and his half-grandniece, Germaine of Foix (1505) Philip II of Spain and his niece, Anna of Austria (1570) Charles II, Archduke of Austria and his niece, Maria Anna of Bavaria (1571) Ferdinand II, Archduke of Austria, and his niece, Anne Juliana Gonzaga (1582) Chiefess Kapohauola and her nephew, Chief Kakae Fernando de Borja y Aragón and his niece, María Francisca de Borja y Aragón John III of Rietberg and his niece, Sabina Catharina of East Frisia (1601) Maximilian I, Elector of Bavaria and his niece, Archduchess Maria Anna of Austria (1635) Prince Maurice of Savoy and his niece, Princess Luisa Cristina of Savoy (1642) Karl Eusebius, Prince of Liechtenstein and his niece, Johanna Beatrix of Dietrichstein (1644) Philip IV of Spain and his niece, Mariana of Austria (1649) Borso d'Este and his niece, Ippolita d'Este (1647) Louis Charles d'Albert, 2nd Duke of Luynes and his aunt Princess Anne de Rohan-Montbazon (1661) Leopold I, Holy Roman Emperor and his niece, Margaret Theresa of Austria (1666). Adolphus Frederick II, Duke of Mecklenburg-Strelitz and his half-grandniece Princess Johanna of Saxe-Gotha (1702) Voltaire (François-Marie Arouet), lived in concubinage with his niece, Marie Louise Mignot Denis. Christian, Landgrave of Hesse-Wanfried-Rheinfels and his niece Countess Maria Franziska of Hohenlohe-Bartenstein (1731) Ferdinand Bonaventura II von Harrach and his niece Maria Rosa von Harrach-Rohrau (1740) Juan López Pacheco, Duke of Escalona and his niece Maria Lopez Pacheco (1748) Pedro Téllez-Girón, 8th Duke of Osuna and his niece María Vicenta Pacheco Téllez-Girón (1753) Prince Augustus Ferdinand of Prussia and his niece Margravine Elisabeth Louise of Brandenburg-Schwedt (1755) Peter III of Portugal and his niece Maria I of Portugal (1760) Károly József Batthyány and his niece Countess Maria Antonia Batthyány von Német-Ujvár Marianna Valguarnera d’Ucrìa and her uncle Pietro Girolamo Valguarnera Frederick Erdmann, Prince of Anhalt-Pless and his niece Countess Louise Ferdinande zu Stolberg-Wernigerode (1766) Prince Benedetto, Duke of Chablais and his half-niece Princess Maria Ana of Savoy (1775) Infanta Benedita and her nephew, José, Prince of Brazil (1777) Prince Eugene of Saxe-Hildburghausen and his niece, Caroline of Saxe-Hildburghausen (1778) Harman Blennerhassett and his niece, Margaret Agnew (1794) Infante Antonio Pascual of Spain and his niece, Infanta Maria Amalie of Spain (1795) King Kamehameha the Great of Hawaii and his half-niece, Queen Keōpūolani (c. 1796) Jorge Tadeo Lozano, President of Cundinamarca (Colombia), and his niece María Tadea Lozano e Isasi (m. 1797) Sir John Acton, 6th Baronet, Prime Minister of Naples and his niece Marianna Acton (1799) Louis Victor Meriadec de Rohan-Guéméné and his niece Bertha de Rohan-Guéméné (1802) Francis IV, Duke of Modena, and his niece, Maria Beatrice of Savoy (titular queen of England and Scotland according to the Jacobite succession) (1812) Ernest Constantine, Landgrave of Hesse-Philippsthal, and his niece, Caroline of Hesse-Philippsthal (1812). Irineu Evangelista de Sousa, Viscount of Mauá, Brazilian entrepreneur, industrialist, banker and politician, and his niece Maria Joaquina "May" de Sousa Machado (1841). Leopold, Prince of Salerno and his niece, Archduchess Clementina of Austria (1816). Infante Carlos, Count of Molina, and his niece, Infanta Maria Francisca of Portugal (1816), and later his niece, Maria Teresa of Portugal (1838) Kamehameha II and his half-niece Kalani Pauahi Ferdinand VII of Spain and his niece Maria Isabel of Portugal (1816), and later his niece Maria Christina of the Two Sicilies (1829). Gustav, Landgrave of Hesse-Homburg and his niece, Princess Louise of Anhalt-Dessau (1818). Leopold, Grand Duke of Baden and his half-grandniece Princess Sophie of Sweden (1819). Infante Francisco de Paula of Spain and his niece Princess Luisa Carlotta of the Two Sicilies (1819). Ernest I, Duke of Saxe-Coburg and Gotha and his niece Duchess Marie of Württemberg (1832). James Mayer de Rothschild, founder of the French branch of the Rothschild banking family, and his niece Betty Salomon von Rothschild (c. 1825). Prince Francis, Count of Trapani and his niece Archduchess Maria Isabella of Austria (1850). Mongkut and his half-grandniece Somanass Waddhanawathy (1851), and his half-grandniece Debsirindra (1851), and later his half-grandniece Phannarai (1851). Svasti Sobhana and his half-niece Abha Barni, and later his half-niece Chavi Vilaya Gagananga. Richard von Metternich (son of the famous Austrian Chancellor) and his niece, Pauline von Metternich (1856). Ignacy Łukasiewicz and his niece, Honorata Stacherska (1857). Porfirio Díaz, 33rd President of Mexico, and his niece, Delfina Ortega Díaz (1867). Duke Nicholas of Württemberg and his half-niece Duchess Wilhelmine of Württemberg (1868). Prince William of Hesse-Philippsthal-Barchfeld and his half-niece Princess Juliane of Bentheim and Steinfurt (1873), and later his half-niece Princess Adelaide of Bentheim and Steinfurt (1879).