U of C refers to a number of institutions of higher education around the world, including the following:

Australia University of Canberra (Australian Capital Territory)

Canada University of Calgary (Alberta)

New Zealand University of Canterbury (Christchurch)

Portugal University of Coimbra

Spain University of Cantabria

United Kingdom University of Cambridge

United States University of California system University of Charleston (West Virginia) University of Chicago (Illinois) University of Cincinnati (Ohio) University of Colorado system, officially uses the acronym CU University of Connecticut