Katherine or Catherine Hughes may refer to:
Kate Duval Hughes (1837–?), American author and inventor Katherine Hughes (activist) (1876–1925), Canadian writer, archivist and political activist Kay Hughes (Catherine Mary Hughes, 1914–1998), American actress Catherine Hughes (diplomat) (1933–2014), British diplomat and principal of Somerville College, Oxford Catherine Hughes Building, a building of Somerville College, Oxford Cathy Hughes (born 1947), American TV personality Kathryn Hughes (born 1959), British historian, journalist and biographer Catherine Andrea Hughes, Guyanese politician Kath Hughes (born 1988), Welsh actress, writer and comedian Katherine Hughes (actress) (born 1995), American actress Kate Hughes (Emmerdale), fictional character on the British TV soap Emmerdale