Yakushev () is a Russian masculine surname, its feminine counterpart is Yakusheva. It may refer to:
Alexander Yakushev (born 1947), Soviet ice hockey player Anatoli Yakushev (born 1980), Russian footballer Marina Yakusheva (born 1974), Russian badminton player Viktor Yakushev (1937–2001), Soviet ice hockey player Vladimir Yakushev (born 1968), Russian politician Vladimir Anatolyevich Yakushev (born 1970), Russian naval officer